Cannabinoid Receptor Antagonist

Cannabinoid Receptor Antagonists (46):

Cat. No.	Product Name	Effect	Purity

HY-15443

AM251	Antagonist	99.25%
AM251 is a selective cannabinoid 1 (CB1) receptor antagonist with an IC₅₀ of 8 nM. AM251 also acts as a potent GPR55 agonist with an EC₅₀ of 39 nM.

HY-14137

Rimonabant Hydrochloride	Antagonist	99.95%
Rimonabant Hydrochloride (SR 141716A Hydrochloride) is a highly potent and selective central cannabinoid receptor (CB1) antagonist with an K_i of 1.8 nM. Rimonabant Hydrochloride (SR 141716A Hydrochloride) also inhibits Mycobacterial membrane protein Large 3 (MMPL3).

HY-18697

JD-5037	Antagonist	98.05%
JD-5037 is a potent CB₁R antagonist with an IC₅₀ of 1.5 nM.

HY-161311

AChE/BChE-IN-18	Antagonist
AChE/BChE-IN-18 (Compound 4g) is a dual inhibitor of AChE/BChE , with a IC₅₀ value of 0.315 μM for AchE. AChE/BChE-IN-18 is also a CB2R antagonist with a K_i value of 31 nM. AChE/BChE-IN-18 has neuroprotective activity.

HY-128040

Virodhamine hydrochloride	Antagonist
Virodhamine (hydrochloride) is a cannabinoid CB1 receptor partial agonist and cannabinoid CB2 receptor full agonist.

HY-13439

SR144528	Antagonist	99.25%
SR144528 is a potent and selective CB2 receptor antagonist with a K_i of 0.6 nM.

HY-14136

Rimonabant	Antagonist	99.41%
Rimonabant (SR141716) is a highly potent, brain penetrated and selective central cannabinoid receptor (CB1) antagonist with a K_i of 1.8 nM. Rimonabant (SR141716) also inhibits Mycobacterial membrane protein Large 3 (MMPL3).

HY-B1161A

S-Methoprene	Antagonist
S-Methoprene is an insect juvenile hormone analog and effective insecticide that blocks the transition from pupa to adult. S-Methoprene is also a CB(1) receptor ligand and inhibits the binding of the CB1 receptor antagonist [³H]CP-55940 to the CB1 receptor (IC₅₀: 19.31 μM).

HY-13505

AM281	Antagonist	≥99.0%
AM281 is a selective CB1 receptor antagonist with an IC₅₀ of 9.91 nM. AM281 inhibits CB2 receptor with an IC₅₀ of 13000 nM.

HY-14791A

(±)-Ibipinabant	Antagonist	99.90%
(±)-Ibipinabant ((±)-SLV319) is the racemate of SLV319. (±)-Ibipinabant ((±)-SLV319) is a potent and selective cannabinoid-1 (CB-1) receptor antagonist with an IC₅₀ of 22 nM.

HY-112340

CB1 antagonist 4	Antagonist	99.00%
CB1 antagonist 4 (compound 8) is a peripheral selective cannabinoid receptor type 1 (CB1) receptor antagonist. CB1 antagonist 4 shows limited penetrance to the brain in order to minimize or prevent CNS adverse reactions, and preserves potential antiobesity effects. CB1 antagonist 4 reduces propensity for psychiatric side effects.

HY-116649

CB1 antagonist 2	Antagonist	99.88%
CB1 antagonist 2 is caimabinoid 1 (CB1) antagonist extracted from patent WO2016184310A1, compound 3, inhibits CB1 in vivo with an IC₅₀ of 25.5 nM.

HY-P1091

Hemopressin (human, mouse)	Antagonist	99.95%
Hemopressin is a nonapeptide derived from the α1-chain of hemoglobin, is originally isolated from rat brain homogenates. Hemopressin is orally active, selective and inverse agonist of CB1 cannabinoid receptors. Hemopressin exerts antinociceptive action in inflammatory pain models.

HY-N6932

Voacamine	Antagonist	99.25%
Voacamine, an indole alkaloid, exhibits potent cannabinoid CB1 receptor antagonistic activity. Voacamine also inhibits P-glycoprotein (P-gp) action in multidrug-resistant tumor cells.

HY-10013A

Taranabant racemate	Antagonist	99.84%
Taranabant racemate (MK-0364 racemate) is an antagonist and/or inverse agonist of the Cannabinoid-1 (CB1) receptor extracted from patent WO 2004048317 A1.

HY-10871

Otenabant	Antagonist	99.23%
Otenabant is a potent and selective cannabinoid receptor CB1 antagonist with K_i of 0.7 nM, exhibits 10,000-fold greater selectivity against human CB2 receptor.

HY-12790

CB1-IN-1	Antagonist	99.31%
CB1-IN-1 (BPRCB1184) is a peripherally restricted CB1R antagonist, with Ki of 0.

HY-152581

CB2R antagonist 3	Antagonist	98.08%
CB2R antagonist 3 is a selective antagonist of cannabinoid type 2 receptor (CB2R). CB2R antagonist 3 has high affinity for human CB2R and specific selectivity for CB1R. CB2R antagonist 3 can be combined with CB65 (HY-110047), the activator of CB2R. CB2R antagonist 3 effectively up-regulates the expression of anti-inflammatory cytokines and down-regulates the expression of pro-inflammatory cytokines.

HY-121827

LH21	Antagonist	98.59%
LH-21 is a potent in vivo neutral cannabinoid CB1 receptor antagonist. LH-21 reduces food intake and body weight gain in obese Zucker rats. , and displays efficacy as a feeding inhibitor.

HY-117139

NESS 0327	Antagonist	≥98.0%
NESS 0327 is a cannabinoid antagonist with high selectivity for the cannabinoid CB1 receptor. NESS 0327 is more than 60,000-fold selective for the CB1 receptor.

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